Posterior subcapsular cataract and inhaled corticosteroid therapy.
نویسندگان
چکیده
BACKGROUND Although posterior subcapsular cataract complicates both systemic and topical corticosteroid therapy, the literature on the effects of inhaled corticosteroids is conflicting. METHODS One hundred and forty children and young adults on inhaled corticosteroids were examined by slit lamp ophthalmoscopy after pupillary dilatation; 103 had received one or more short courses (< or = 7 days) of oral corticosteroids in the management of acute asthmatic attacks and four had also received one or more prolonged courses (> or = 4 weeks) of alternate day oral corticosteroid therapy. RESULTS Bilateral posterior subcapsular cataract was identified in one girl who had received several prolonged courses of oral corticosteroids, but was not identified in any other patient. CONCLUSIONS There is no evidence to support the contention that inhaled corticosteroid therapy on its own, or in association with short courses of oral corticosteroid therapy, might cause cataracts. Although children receiving long term systemic corticosteroid therapy should be screened for cataracts, this is unnecessary in children on inhaled corticosteroids alone.
منابع مشابه
Posterior subcapsular cataracts and macular lesions after long-term corticotrophin therapy.
POSTERIOR subcapsular cataracts in patients receiving long-term oral corticosteroid therapy have been reported by several workers (Black, Oglesby, Sallmann, and Bunim, 1960; Gordon, Kammerer, and Freyberg, 1961; Giles, Mason, Duff, and McLean, 1962; Toogood, Dyson, Thompson, and Mularchyk, 1962; Crews, 1963). Increased intra-ocular pressure has also been noted (Alfano, 1963; Becker and Shaffer,...
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Posterior subcapsular cataracts, bruises and hoarseness in children with asthma receiving long-term treatment with inhaled budesonide.
We assessed the effect of long-term treatment with inhaled budesonide (BUD) on the occurrence of posterior subcapsular cataracts (PSC), bruises and hoarseness in children with asthma. Slit lamp examinations were performed in 157 asthmatic children treated with inhaled BUD at a mean daily dose of 504 microg (range 189-1,322 microg) for 3-6 yrs (mean 4.4 yrs). Measurements were compared with 111 ...
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Introduction: Exposure to systemic corticosteroids is known to be associated with a risk of cataract. This study was undertaken to determine the risk of cataract associated with the use of inhaled corticosteroids in old age. Methods: A case-control study consisting of 160 people with cataract (case) and 160 controls matched for age and sex was conducted at Shaheed Sadoughi and Shaheed Rahnemoo...
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Th incidence and severity of posterior subcapsular cataracts were studied in 58 children with steroid-sensitive nephrotic syndrome. Eight (14%) children had cataracts. Visual acuity was normal in all but one child. There was no relationship between total dose or mean daily dose of prednisolone (corrected for body surface area) and cataract formation. Alternate-day treatment with prednisolone fo...
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ورودعنوان ژورنال:
- Thorax
دوره 50 6 شماره
صفحات -
تاریخ انتشار 1995